Alzheimer's Disease: Sugar & Turmeric - What You Need To Know

Having sugar on the mind is one thing, but metabolizing sugar in the brain is a little less sweet. In a study published in the medical journal, Frontiers in Aging Neuroscience, researchers found an overactivation of fructose in the brain may contribute to Alzheimer's disease.

A team of neurologists, neuroscientists, and experts on fructose metabolism conducted the research. The evidence not only points to the link between excess sugar and cognitive decline, but it also helps explain the association between metabolic health and Alzheimer's.

๐—ช๐—›๐—”๐—ง ๐—˜๐—ซ๐—”๐—–๐—ง๐—Ÿ๐—ฌ ๐—œ๐—ฆ โ€œ๐—™๐—ฅ๐—จ๐—–๐—ง๐—ข๐—ฆ๐—˜ ๐— ๐—˜๐—ง๐—”๐—•๐—ข๐—Ÿ๐—œ๐—ฆ๐— โ€?

There are two common types of sugars: fructose and glucose.

Fructose is a natural sugar, commonly found in fruit, fruit juices, and honey. But it also makes up 50% of most table sugars, meaning it can be present in processed foods, sodas, baked goods, and high-fructose corn syrupโ€”pretty much anything with added sugars.

Glucose, on the other hand, is a type of simple sugar that's less sweet than fructose. When it travels to the bloodstream, it becomes what we commonly know of as blood sugar.

A 2017 Yale study found that when people have elevated blood sugar levels for hours at a time, the brain starts to overproduce fructose. This mechanism is called fructose metabolism and is common in type 2 diabetics.

๐—›๐—ข๐—ช ๐——๐—ข๐—˜๐—ฆ ๐—ง๐—›๐—œ๐—ฆ ๐—œ๐— ๐—ฃ๐—”๐—–๐—ง ๐—”๐—Ÿ๐—ญ๐—›๐—˜๐—œ๐— ๐—˜๐—ฅโ€™๐—ฆ ๐—ฅ๐—œ๐—ฆ๐—ž?

When fructose metabolism occurs due to excess sugar consumption, the brain essentially goes into overdrive. The process of neural glycolysis uses up necessary cerebral energy, making brain neurons less functional or viable over time, study author Richard Johnson, M.D., explains in a news release.

"In essence, we propose that Alzheimer's disease is a modern disease driven by changes in dietary lifestyle in which fructose can disrupt cerebral metabolism and neuronal function," his study states.

The research suggests excess consumption of fructose can increase fructose metabolism in the brain. The process ultimately takes energy away from other, more necessary, brain functions. Over time, this may lead to the development of Alzheimer's disease, though more research needs to be done to confirm the theory.

"By outlining consistent evidence, we're hoping to inspire researchers to continue exploring the relationship between fructose in the brain and Alzheimer's disease," Johnson says. "New treatments aimed at inhibiting intracerebral fructose metabolism could provide a novel way to prevent and treat this disease."

In the meantime? Cutting back on sugar (sorry, sweet tooths) may be one way to stave off these unwanted neurodegenerative effects. Other lifestyle habits, like regular exercise, staying positive, and even drinking coffee can also help support the brain.

๐—ช๐—›๐—”๐—ง ๐—”๐—ฅ๐—˜ ๐—ง๐—›๐—˜ ๐—–๐—Ÿ๐—”๐—œ๐— ๐—ฆ ๐—”๐—•๐—ข๐—จ๐—ง ๐—ง๐—จ๐—ฅ๐— ๐—˜๐—ฅ๐—œ๐—–, ๐—–๐—จ๐—ฅ๐—–๐—จ๐— ๐—œ๐—ก, ๐—”๐—ก๐—— ๐——๐—˜๐— ๐—˜๐—ก๐—ง๐—œ๐—” ๐—ฅ๐—œ๐—ฆ๐—ž?

Many different studies have explored the potential role of turmeric as a treatment for Alzheimer's disease. Most research is centered around curcumin, which is one of the most beneficial components of turmeric.

Most of the studies investigating curcumin have been performed in mice or in cells. These have suggested that curcumin can reduce inflammation and oxidative stress.

Some findings have also suggested that curcumin may be able to prevent the formation and even break up amyloid-beta plaques, the toxic protein clumps that build up in Alzheimerโ€™s disease.

The way that curcumin may work within the brain is unclear and we need more research looking into its mechanism.

There are several research studies currently being carried out looking at the anti-inflammatory role of curcumin. These will hopefully provide more insight into the benefit of curcumin in adults with dementia.

Natural products have been used as diets and dietary supplements to treat human diseases, including cancer, cardiovascular, respiratory, infectious, diabetes, obesity, metabolic syndromes, and neurological disorders. Plant and herbal products are known to have multiple protective effects, including anti-inflammatory, anti-oxidant, anti-arthritis, and the ability to boost memory. Recent curcumin research revealed that curcumin boosts cognitive functions in humans.

๐— ๐—ข๐—ฅ๐—˜ ๐—ง๐—›๐—”๐—ก ๐—ง๐—จ๐—ฅ๐— ๐—˜๐—ฅ๐—œ๐—–โ„ข & ๐— ๐—ข๐—ฅ๐—˜ ๐—ง๐—›๐—”๐—ก ๐—š๐—ฅ๐—˜๐—˜๐—ก๐—ฆโ„ข โ€” ๐—ง๐—›๐—˜ ๐——๐—ฌ๐—ก๐—”๐— ๐—œ๐—– ๐——๐—จ๐—ข ๐—œ๐—ก ๐—™๐—œ๐—š๐—›๐—ง๐—œ๐—ก๐—š ๐—œ๐—ก๐—™๐—Ÿ๐—”๐— ๐— ๐—”๐—ง๐—œ๐—ข๐—ก

Studies have shown that certain herbs and spices can help prevent the onset of dementia and Alzheimerโ€™s. Itโ€™s believed the best time to start using these natural remedies is during midlife, well before the signs of memory loss surface.
๐— ๐—ผ๐—ฟ๐—ฒ ๐—ง๐—ต๐—ฎ๐—ป ๐—š๐—ฟ๐—ฒ๐—ฒ๐—ป๐˜€โ„ข and ๐— ๐—ผ๐—ฟ๐—ฒ ๐—ง๐—ต๐—ฎ๐—ป ๐—ง๐˜‚๐—ฟ๐—บ๐—ฒ๐—ฟ๐—ถ๐—ฐโ„ข, used individually or, better yet, taken together, contain some of the most studied natural compounds to reduce inflammation, slow the buildup of amyloid plaque which causes memory loss, and flood the body with antioxidants to combat free radicals that damage cells.

๐—ฉ๐—ถ๐˜€๐—ถ๐˜ ๐—ฎ๐—ป๐—ฑ ๐—น๐—ฒ๐—ฎ๐—ฟ๐—ป ๐—ฎ๐—ฏ๐—ผ๐˜‚๐˜ ๐— ๐—ผ๐—ฟ๐—ฒ ๐—ง๐—ต๐—ฎ๐—ป ๐—š๐—ฟ๐—ฒ๐—ฒ๐—ป๐˜€โ„ข ๐—ฎ๐—ป๐—ฑ ๐— ๐—ผ๐—ฟ๐—ฒ ๐—ง๐—ต๐—ฎ๐—ป ๐—ง๐˜‚๐—ฟ๐—บ๐—ฒ๐—ฟ๐—ถ๐—ฐโ„ข โ€” ๐—ฌ๐—ผ๐˜‚๐—ฟ ๐—ฏ๐—ฟ๐—ฎ๐—ถ๐—ปโ€™๐˜€ ๐—ถ๐—ป๐˜€๐˜‚๐—ฟ๐—ฎ๐—ป๐—ฐ๐—ฒ ๐—ฝ๐—ผ๐—น๐—ถ๐—ฐ๐˜† ๐—ฎ๐—ด๐—ฎ๐—ถ๐—ป๐˜€๐˜ ๐—ฑ๐—ฒ๐—บ๐—ฒ๐—ป๐˜๐—ถ๐—ฎ ๐—ฎ๐—ป๐—ฑ ๐—”๐—น๐˜‡๐—ต๐—ฒ๐—ถ๐—บ๐—ฒ๐—ฟโ€™๐˜€.


Mind Body Green. Too Much Sugar In The Brain May Contribute To Alzheimer's, Study Finds. Abby Moore. September 24, 2020

Alzheimerโ€™s Society UK. Turmeric and Dementia.

Journal of Alzheimerโ€™s Disease. Protective Effects of Indian Spice Curcumin Against Amyloid Beta in Alzheimerโ€™s Disease. P. Hemachandra Reddy, Maria Manczak, et al. October 10, 2017

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